- This War of Mine, you're not a superhero, you're just trying to survive in a warzone.
— Hashp1per - Honest Hearts expansion for Fallout: New Vegas.
There's a series of journal entries left behind by this dude, chronicling what happened to his first, and then second family after the bombs fell. Just heartbreaking.
— SJane3384 - The part in Shadow of the Colossus where Agro throws you to safety and then falls
— stiicky - Halo Reach: all the characters you begin to love throughout the campaign start dying one by one until you are the last one left, then you die
— Ramennoodler1 - Bioshock hit me pretty hard. Harvesting the girls to become much stronger or to save them and become a little more stronger. The ending made a difference as well. I saved all of the girls on my playthrough and it was tough but I truly enjoyed it.
Also, the idea of a utopia turned into a dystopia, freedom from religion, politics and government made it into a damn fine game and seeing what people did during the come up and downfall was pretty interesting.
— Needlecrash - Red dead redemption, that first ride into Mexico will make you feel something.
— Amsp228 - Infamous 2. Whether you go the Good way or the Evil one, the ending just hits you right in the heart.
— Introvertedgenius - Weirdly enough, Portal 2.
It made me feel so alone. Then there was the reveal that [SPOILER] GLaDOS used to be a human, who had her consciousness put in a computer. Watching her realize that she used to be alive was emotionally intense for me. It was like watching a ghost wishing to be alive again.
Had a little existential crisis regarding artificially sustained consciousness, artificial intelligence, and immortality.
— Dickcheese_McDoogles